NR4A1 and hereditary pheochromocytoma-paraganglioma: Nur77 can reportedly enhance neuronal outgrowth and differentiation: both dibutyryl-cAMP (dbcAMP) and trichostatin A (TSA) promote neurite outgrowth in PC12 rat pheochromocytoma cells by inducing Nur77 expression via acetylated Lys14 of histone H3, and knockdown of Nur77 inhibits dbcAMP and TSA-induced neurite outgrowth [73, 74].