Among the biomarkers studied, highest tertiles of hs-CRP (odds ratio [OR], 1.47; 95% confidence interval [CI], 1.19 to 1.81; P<0.001) and IL-6 (OR, 1.87; 95% CI, 1.50 to 2.32; P<0.001) had significant univariate associations with past history of AF. This evidence concerns the gene IL6 and atrial fibrillation.