In the unadjusted model, hs-CRP (OR, 1.16; 95% CI, 1.00 to 1.35; P = 0.05) and IL-6 (OR, 1.37; 95% CI, 1.16 to 1.63; P<0.001) were associated with new onset AF. This evidence concerns the gene IL6 and atrial fibrillation.