Assuming 20% of all ischemic strokes are wake-up strokes, and that the MRI-based strategy would result in 31% of these wake-up strokes being treated with tPA, and that 5.5% of ischemic strokes treated with tPA experience sICH, we estimated that the MRI-strategy would result in a 0.34 percentage point increase of sICH among ischemic stroke patients. Here, PLAT is linked to Stroke.