IAPP and Alzheimer disease: However, the correlations between AD and T2D, the shared amyloidogeneic nature of Aβ and human IAPP, the reported degrading capacity of BACE2 on Aβ, and the co-localization of BACE2 and IAPP in beta-cells, led us to explore a positive role for BACE2 activity in islet amyloidosis.