Finally, to shed light on the mechanistic background, we performed qRT-PCR for established JNK target genes, including c-Jun, Survivin, CKD1, MMP1, and c-Myc, in untreated and low-dose (0.5 μM) JNKi-treated pancreatic cancer cells [23]. Here, MMP1 is linked to familial pancreatic carcinoma.