In this work, we found that low-dose JNK inhibition (JNKi) significantly decreased growth patterns in different pancreatic cancer cell lines in adherent culture (Figure 1A, 1B and Supplementary Figure S1A, B) or nonadherent, CSC-enriched sphere culture (Figure 2B-2C and Supplementary S2B). Here, MAPK8 is linked to pancreatic neoplasm.