We compared the histologic features of EHE cases according to their TFE3 expression state but observed varying degrees of myxohyalinized stroma, tumor necrosis, mitotic activity, spindle and epithelioid cytologic features, and foamy and eosinophilic cytoplasm that seemed irrelevant to their TFE3 expression (P > 0.05, Table 5 and Supplementary Data 1). The gene discussed is TFE3; the disease is neoplasm.