As a universally recognized biomarker of CSCs, CD133 has been extensively utilized to identify and isolate CSCs in a variety of human tumors, including brain tumors, prostate tumors, pancreatic adenocarcinomas, colorectal carcinomas, hepatocellular carcinomas, melanomas, breast cancers, lung cancers, laryngeal carcinomas, and osteosarcomas [6, 15, 25–28]. This evidence concerns the gene PROM1 and colorectal carcinoma.