HMGB1 and neoplasm: In GSE30219, HMGB1 expression in ADC and SCC was found to be significantly different (Figure 3A, P=0.000); it was also found to be significantly different in tumor size (T stage, P=0.000), lymph node involvement (N stage P=0.000) and distant metastasis (M stage P=0.022) (Figure 3B–3D).