In addition to the mutations described in the landmark studies from the Vogelstein group, e.g., p53, pRb, DCC, APC, etc., many novel oncogenic mutations continue to be discovered especially with the development of powerful techniques that facilitate large-scale genomic studies, which have revealed a plethora of new oncogenes, including many in processes that were not previously known to be involved in cancer [5, 6]. The gene discussed is RB1; the disease is cancer.