APLP2 and familial pancreatic carcinoma: Since transfected cells expressing various APLP2 isoforms had an increased migratory response when the isoform that was overexpressed was APLP2-751 (which bears the chondroitin sulfate glycosaminoglycan modification) [50], it is possible that the presence of the chondroitin sulfate glycosaminoglycan modification may also increase the migratory tendencies of pancreatic cancer cells.