Our research group has demonstrated that in addition to overexpression of APP in pancreatic cancer cell lines, there is overexpression of APLP2 (both full-length and cleaved forms) in pancreatic cancer cell lines, and by immunohistochemistry we have demonstrated overexpression of APLP2 in human pancreatic tumor samples [42, 61]. The gene discussed is APLP2; the disease is familial pancreatic carcinoma.