Likewise, quantitative microarray followed by reverse transcriptase-polymerase chain reaction showed a >10% decrease in APP mRNAs containing exon 8 in non-squamous cell lung carcinoma, breast cancer, and colon cancer (as compared to patient-matched controls), indicating a predilection towards APP-751 expression in each of these cancers [58]. This evidence concerns the gene APP and squamous cell lung carcinoma.