RB1 and non-small cell lung carcinoma: Using APP-specific siRNA transfection of non-small cell lung cancer (NSCLC) cells, this group showed that upon APP downregulation there was destabilization of cyclin C, leading to G0/G1 cell cycle arrest, as well as to decreased phosphorylation of pRb, abnormalities in cell size, and necrosis due to membrane permeabilization [74].