Deciphering the specific pathways in which APP and APLP2 function in cancer cells to increase malignancy (and, with APLP2, also to increase cancer immune evasion [76, 84-86]) will be necessary to fully comprehend the roles of these proteins in cancer progression and to develop new therapeutic regimens for cancer that are based on targeting APP and/or APLP2. This evidence concerns the gene APLP2 and cancer.