Consistent with the diminished sensitivity of ER+ breast cancer cells to B6H12 observed in vitro, CD47 mRNA expression in the TCGA dataset was negatively correlated with ER and with HER2 protein expression (p = 1.7×10−6 and 2.5×10−5, respectively, Figure 7B, Figure 8A). This evidence concerns the gene ESR1 and breast cancer.