In our previous studies, we found that increased HOTAIR and MVIH promoted NSCLC cells invasion and metastasis via regulating HOXA5, MMP2 and MMP9 expression, and lncRNA ANRIL over-expression increased NSCLC cells proliferation by interacting with EZH2 and recruiting it to KLF2 promoter to repress its transcription [18–20]. Here, HOTAIR is linked to non-small cell lung carcinoma.