GAPDH and ovarian neoplasm: The 281 base pair predicted GAPD mRNA cleavage product was detected using the 5′RLM-RACE assay in ovarian tumor tissue derived from mice treated with Trast-SA bearing nanoparticles containing GAPD siRNA but not in mice treated with Trast-SA nanoparticles containing negative control siRNA or Trast-SA alone thus verifying RNAi-mediated GAPD gene suppression (Figure 6c).