A model with interaction term of gene expression of IGF2 and H19 found that IGF2 and the joint action of IGF2 and H19 in placenta showed significantly relationship with GDM/NGT and GDM-NBW/NGT-NBW, a borderline significant association was seen among IGF2 and H19 in cord blood and GDM-M/NGT-M. This evidence concerns the gene IGF2 and gestational diabetes.