IGF1 and Central hypothyroidism: In males the phenotype is characterized by congenital central hypothyroidism, delayed testosterone rise in puberty but normal timing of testicular enlargement, adult macroorchidism, partial GH deficiency (GHD) in some patients during childhood (but with high-normal IGF-1 concentrations in adulthood) or lifelong prolactin deficiency, and overweight habitus (1, –, 5).