CREB1 and acute myeloid leukemia: To identify compounds that specifically disrupt CREB-driven transcription, we generated a KG-1 AML cell line expressing Firefly luciferase in a CREB-specific manner (KG-1 CRE), and a separate KG-1 cell line expressing Firefly luciferase under the control of the CMV promoter (KG-1 CMV), as described in Methods. The Stanford University's High-Throughput Bioscience Center's (HTBC) Small Molecule Library was first screened against KG-1 CRE cells for 24 hours.