Based on the foregoing experimental data, we concluded that AS1411 aptamer-medicated nanocarrier can facilitate TP accumulating in tumor tissues via EPR effect, when they entered the tumor interstitial space, AS1411 aptamer presented on the AS-PPT surface quickly recognized cancerous cell followed by AS1411-nucleolin interaction, and consequently enhanced the inhibition of tumor growth. Here, NUCLEOLIN is linked to neoplasm.