First of all, data from qPCR, IHC and western blotting assays of paired clinical ESCC tissues, collected from patients who were diagnosed between January 2009 and December 2011 at the Department of Pathology, Anyang Tumor Hospital, Fourth Affiliated Hospital of Henan University of Science and Technology [10], revealed that the expression of CRABP2 was strikingly downregulated at both mRNA and protein levels. The gene discussed is CRABP2; the disease is esophageal squamous cell carcinoma.