On the contrary, some other investigators have shown that CRABP2 is highly upregulated and correlated with poor outcome in primary retinoblastoma tumors [15], non-small cell lung cancer [1], advanced breast cancer [21] and Wilms tumors [16].Therefore, the roles of CRABP2 in tumorigenesis, depending on the genetic background and the tumor pathotype, are more complicated than we have expected. This evidence concerns the gene CRABP2 and breast cancer.