On the contrary, some other investigators have shown that CRABP2 is highly upregulated and correlated with poor outcome in primary retinoblastoma tumors [15], non-small cell lung cancer [1], advanced breast cancer [21] and Wilms tumors [16].Therefore, the roles of CRABP2 in tumorigenesis, depending on the genetic background and the tumor pathotype, are more complicated than we have expected. This evidence concerns the gene CRABP2 and non-small cell lung carcinoma.