Moreover, conditional deletion of α-KL from the DT using Ksp-Cre (α-KlDT-cKO) results in hyperphosphatemia and increased expression of vitamin D regulatory enzymes in association with elevated FGF-23 levels, indicating that loss of α-KL in the distal tubule can affect proximal tubule functions [25]. This evidence concerns the gene FGF23 and hyperphosphatemia.