INS and cancer: Insulin has the following functions: on one side, it promotes synthesis of insulin-like growth factor 1, which correlates with fat accumulation, and increase of white adipose tissue; on other side, it is the leader in the deregulations in the secretion of adipokines and metabolic markers that has been associated with certain types of cancer and other chronic diseases such as T2DM [1, 4, 6, 38].