We, therefore, performed a randomised, parallel-group trial using continuous glucose monitoring (CGM) to assess the blood glucose fluctuations in T2DM patients, who achieved euglycemic control treated with two procedures of intensive insulin therapy, that is, MDI, aspart 30-based MDI3 (three injections daily), and glargine based MDI4 (four injections daily). This evidence concerns the gene INS and type 2 diabetes mellitus.