ACE and hypertensive disorder: Ramipril (RAM), (2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid, is an orally active inhibitor of angiotensin converting enzyme (ACE), which is a prodrug used in the treatment of all forms of hypertension, heart failure, and following myocardial infarction to improve survival in patients with clinical evidence of heart failure [10, 11].