ACE and hypertensive disorder: Hydrochlorothiazide (HCZ) is a benzathiadiazine diuretic, chemically known as 6-chloro-1,2,3,4-tetrahydro-2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, used in hypertension and often prescribed in combination with other antihypertensive drugs such as beta blockers, angiotensin-converting enzyme inhibitors, or angiotensin II receptor blockers [13, 14].