Walters et al. [4] also reported that the serum of a patient with Hodgkin's disease with severe fasting hypoglycemia has a factor found on the immunoglobulin fraction that enhanced the uptake of glucose in rat adipocytes and these substances displaced the insulin bound in the human erythrocyte and precipitated and phosphorylated human insulin receptors. The gene discussed is INS; the disease is Hodgkins lymphoma.