To further characterize the mechanisms by which peel polyphenols inhibited cell growth, induced apoptosis and arrested cell cycle progression, we tested the involvement of MAPK (JNK, p38, and ERK1/2) cascades, PI3K/AKT and NF-κB signaling pathway that play critical role in colorectal cancer [20]. The gene discussed is AKT1; the disease is colorectal cancer.