The most important signaling pathways regulating cell proliferation and survival implicated in colorectal cancer involve Wnt/β-catenin, phosphatidyl-inositol-3-kinase (PI3 K), growth factor receptors/Ras/mitogen-activated protein kinases (MAPK), JAKs/STAT3 and especially nuclear factor κB (NF-κB) [7]. The gene discussed is STAT3; the disease is colorectal cancer.