COL4A1 and autosomal dominant familial hematuria-retinal arteriolar tortuosity-contractures syndrome: Besides polyuria and proteinuria, mice also develop haematuria (Fig. 4D,E), similar to humans with HANAC syndrome (Plaisier et al., 2010, , 2007), as indicated by dipstick analysis of urine samples collected in metabolic cage studies [Col4a1+/Svc (6/6) Col4a1+/Raw (1/8) and wild-type (0/10); Fig. 4E].