ZEB1 and cancer: EMT is again required later in development, for neural crest cell migration, and is then facilitated by Snail, Slug (also known as Snail2) and the Zeb family of transcription factors; Snail and Zeb family proteins have also been implicated in cancer cell invasion and dissemination (Cheung et al., 2005; Comijn et al., 2001; Hajra et al., 2002).