Notch's role in tumor progression seems to be context-dependent, as the pathway can act as an oncogene in some settings (e.g. breast cancer and T-cell leukemia) or as a tumor suppressor gene in others (e.g. skin cancer) (Avila and Kissil, 2013; Bolós et al., 2007; Radtke and Raj, 2003), although the latter might be through a non-cell-autonomous mechanism (Demehri and Kopan, 2009). The gene discussed is ENSG00000280371; the disease is neoplasm.