MTHFR C677T was significantly associated with lacunar stroke (odds ratio [OR] 1.20, 95% CI 1.09–1.33; P=0.0003), but not with large-artery stroke (OR 1.01, 95% CI 0.93–1.08; P=0.88) or cardioembolic stroke (OR 1.03, 95% CI 0.96–1.11; P=0.44; Figure 1). Here, MTHFR is linked to large artery stroke.