Stratifying the lacunar stroke cases for hypertension status demonstrated the association of MTHFR C677T with lacunar stroke was present in hypertensives (OR 1.24, 95% CI 1.11–1.38; P=0.0002), but not in normotensives (OR 1.09, 95% CI 0.92–1.29; P=0.30). The gene discussed is MTHFR; the disease is hypertensive disorder.