We identified the p85-SHP2 interaction through PI3K complex IPs from overlapping immunoprecipitations (IP) and microcapillary liquid chromatography/tandem mass spectrometry (LC-MS/MS) experiments, from drosophila S2R+ cells and a variety of human lung cancer and multiple myeloma cell lines using reciprocal BLAST searches29, 30, 31. The gene discussed is PIK3CD; the disease is AL amyloidosis.