We evaluated the p85 and SHP2 associated complex in BCR-ABL positive multiple myeloma H929 cells, NCI H929 cells, human embryonic kidney 293T cells, multiple myeloma MOLP8 cells and chronic myeloid leukemia K562 cells with immunoblots of p85, p110, SHP2 and GAB2 from p85 and SHP2 IPs (Fig. 2B,C) and the higher association of SHP2 with the p85 regulatory subunit of PI3K could be verified in all the cell lines. This evidence concerns the gene PIK3R2 and plasma cell myeloma.