MKI67 and cancer: Different from traditional computer software, which only obtained Ki67 sum of the specific tumor tissue (the Ki67 sum is influenced by the number of cancer cells in the analytic targets)21, the new automatic Ki67 counting methods aimed at recognizing/counting both Ki67-positive and negative cancer cells, thus making the Ki67 counting more objective, efficient, and accurate12, 18, 22, 23, 24.