LTA and clostridium difficile infection: We have previously demonstrated that a mucosal adjuvant such as a non-toxic mutant of E. coli heat labile enterotoxin, LT (r192g) is needed to induce a potent mucosal immune response in the form of IgA present in the stool of toxin-immunized mice.21,36 Further studies need to be performed to delineate the mechanism of protection of anti-FliC-induced IgA against CDI using mucosal adjuvants.