IDH1 and central nervous system cancer: To investigate whether germline genetic risk variants are linked to specific molecular characteristics of the tumor, we selected 13 glioma risk variants established in the previous studies, mainly GWAS (Supplementary Table 1), and studied their correlation with the glioma somatic biomarkers: EGFR alteration, 1p/19q codeletion, IDH1 mutation, p53 and Ki67 protein expression.