INS and Hyperglycemia: It was expected that reduction in this patient’s long-term basal insulin rate would result in severe hyperglycemia and/or ketosis, so the insulin formulation administered by CSII was switched from insulin lispro to insulin glulisine, with which the allergic reaction is milder, and no allergic symptoms such as redness and swelling were subsequently found at the cannula insertion site (Fig. 1b).