Although the loss of PKR did not affect glucose tolerance following 16 weeks of either the SCD (Fig. 2e) or HFD (Fig. 2g), we did observe significantly lower plasma insulin levels in PKR KO mice compared with their WT counterparts following 16 weeks of HFD (Fig. 2h; genotype main effect, P=0.018). Here, INS is linked to Schnyder corneal dystrophy.