TARDBP and neurodegenerative disease: In 2006, furthermore, TDP-43 was found as an aggregated protein consisting of abnormal inclusions in several neurodegenerative diseases such as frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS)5, 6, and later, mutations in the TDP-43 gene were identified as a cause of familial forms of FTLD and ALS7, 8, 9, 10.