EPHX1 and hypertensive disorder: Finally, the common human EPHX1 polymorphisms indicate a potential involvement of mEH in the regulation of vascular tone: distinct human EPHX1 polymorphisms associated with slightly enhanced enzymatic activity predispose its carrier to pre-eclampsia, a pregnancy-related pathology with hypertension as a leading symptom (Groten et al. 2014; Pinarbasi et al. 2007; Zusterzeel et al. 2001).