Interestingly, a study of families affected by Specific Language Impairment recently reported a significant overrepresentation of CNVs involving genes functioning in acetylcholine binding, including the α3, α7 and β4 nicotinic acetylcholine receptors, (GO:0042166, CHRNA7, CHRNA3, ACHE and CHRNB4) implicating a role for this pathway in speech and language disorders30. Here, CHRNB4 is linked to specific language impairment.