HTR2A and nervous system disorder: Taken together, our findings demonstrate 5-HT2 receptors functionally modulated GABAergic synaptic transmission in the neural networks composed of human iPS-derived neurons, suggesting that iPS-derived neurons would receive diffused serotonin neuromodulation after transplantation just like host cells, but also could sever as an ideal in vitro model for studying neurological diseases and screening serotonin related neuropsychological drugs.