KPH2 tumours displayed increased c-Myc protein levels on average, but only modest changes in the expression of several canonical c-MYC target genes (Myc, Ccnd1, Ccdn2, Mcm5 and Cdkn1a; Supplementary Fig. 3c) were observed (for more discussion on this matter, see below). The gene discussed is MCM5; the disease is neoplasm.