Of note, EPAS1 levels were significantly lower in more aggressive liposarcoma subtypes, such as dedifferentiated and pleomorphic liposarcoma (Fig. 2c and Supplementary Fig. 2b), and in this data set, the bottom 50% EPAS1 expressing cohort have a higher risk of death (relative risk of 6.67) compared with the top 50% EPAS1 expressing cohort. Here, EPAS1 is linked to liposarcoma.