Given that HIF-2α expression opposes STS tumourigenesis, we sought a class of compounds that could induce re-expression of HIF-2α in sarcoma cells, and found that the FDA-approved HDACi SAHA (Vorinostat) reactivates EPAS1 expression in STS cells, inhibiting sarcoma progression (Fig. 6h). The gene discussed is EPAS1; the disease is telomere syndrome.