TGM2 and Alzheimer disease: In previous work of our group, we demonstrated that tTG and its cross-links are not only present in both classic SPs and CAA in AD cases, but also colocalise with Aβ in diffuse SPs, suggested precursors of classic SPs, and early stages of CAA suggesting that tTG may be important in the onset of the Aβ cascade and/or early stages in the formation of SPs and CAA.