However, although in both mouse models and AD cases a similar presence and activity of tTG in astrocytes associated with Aβ depositions has thus been demonstrated by us, more research is necessary to demonstrate whether the tTG in reactive astrocytes in human AD and in these mouse models is directly triggered by Aβ or via tissue damage evoked by Aβ deposition. Here, TGM2 is linked to Alzheimer disease.