For istance, distruption of VEGFR-signaling leads to the reduction of capillary density causing contractile dysfunction, fibrosis and heart failure, whereas distruption of PDGFR-signaling triggers apoptosis and necrosis of the cardiac myocytes, or HIF-inhibition may impair myocardial response to acute or chronic ischemia.52 The gene discussed is PDGFRB; the disease is heart failure.