Importantly, asthma is a heterogeneous disease and in addition to the Th2-mediated eosinophilic paradigm, neutrophilic-predominant inflammation is a feature of one third of patients with asthma.6, 7, 8, 9 Although the cause of neutrophilic asthma is unclear, it is associated with increased presence of proinflammatory and Th1 cytokines in sputum and bacterial colonization.10 This evidence concerns the gene NELFCD and asthma.