DUOX1 protein expression was increased in the epithelium in patients with nonneutrophilic (29.0% ± 7.4%) and neutrophilic (22.3% ± 4.7%) asthma vs healthy control subjects (9.8% ± 3.2%; P = .026 and P = .041, respectively); it was not differentially expressed in neutrophilic vs nonneutrophilic phenotypes (P = .465) (ANOVA, P = .048) (Figs 3B, 3D) and did not correlate with sputum neutrophil count (r = –0.06; P = .832). The gene discussed is DUOX1; the disease is asthma.