However, NPM1 is known to influence ribosome biogenesis, genome stability and tumor suppression (Lindstrom, 2011) and to participate in responses to cellular stresses, including DNA damage (Lee et al., 2005), chemotoxicity (Chan, 1992; Yao et al., 2010b), and oxidative stress (Paron et al., 2004). This evidence concerns the gene NPM1 and neoplasm.