ADRB1 and cardiac hypertrophy: Of note, using magnetic resonance imaging, Wiesmann and colleagues (Wiesmann et al., 2001) have previously reported analogous findings, by showing that the acute i.p. administration of dobutamine helps unmask evidence of diastolic dysfunction in a distinct mouse model of compensatory cardiac hypertrophy without abnormalities in basal LV function (4-month-old transgenic mice with cardiac-specific overexpression of the β1-AR).