Kang et al. identified 31 DS differentially expressed maternal serum proteins (DS-DEMSPs) using the latest proteomic techniques to identify proteins differentially expressed in the maternal serum of women carrying a DS fetus, ten of which were considered as potential biomarkers (Alpha-2-macroglobulin, Apolipoprotein A1, Apolipoprotein E, Complement C1s subcomponent, Complement component 5, Complement component 8, alpha polypeptide, Complement component 8, beta polypeptide and Fibronectin) [66]. The gene discussed is APOE; the disease is Dravet syndrome.