miR-222, a frequently overexpressed miRNA in HCC, also regulates cell motility by enhancing Akt signaling [90], whereas miR-423 directly binds to 3'-UTR of p21Cip1/Waf1 to suppress its expression and to promote cell cycle progression and tumorigenesis [91]. This evidence concerns the gene CDKN1A and hepatocellular carcinoma.