ERBB2 and non-small cell lung carcinoma: Clinical trials with HER2-targeted monoclonal antibodies, trastuzumab and pertuzumab, also have shown efficacy in some NSCLC patients [70,73,74]; however, trials with trastuzumab have been insufficiently powered to determine whether NSCLC patients with HER2 gene amplification or overexpression as determined by immunohistochemistry may benefit from treatment [75,76].