GAST and neoplasm: Detailed analysis of the antibody epitopes through alanine scanning of gastrin (Barderas et al., 2008b) and docking of the epitope into the antibody binding site, followed by affinity maturation through phage display and in silico methods (Barderas et al., 2008a) resulted in the development of antibody fragments with enhanced potency to inhibit gastrin-induced tumor growth.