CD4 and HIV-1 infection: While the triazacyclophane scaffold peptide did not affect HIV-1 infection (Chamorro et al., 2009), CD4bs-M was surprisingly found to strongly enhance HIV-1 infection of both CD4 positive and CD4 negative cells, and this effect could be linked to a strong tendency of the peptide to assemble into amyloid fibrils (Groß et al., 2015b).