NR4A1 and breast carcinoma: Thus, many breast cancer factors such as age at onset, menopausal status (Clavel-Chapelon 2002; Althuis et al. 2004), and timing and number of births (Pathak et al. 2000; Palmer et al. 2003), affect the risk of breast cancer in an opposite direction (increasing or decreasing risk) depending on its hormonal receptor status (Anderson et al. 2014).