Additionally, the TCGA study identified loss ofTRAF3 gene, amplification ofE2F1 in human papilloma virus (HPV)-positive oropharyngeal tumors, along with mutations inPIK3CA,CASP8 andHRAS, and co-amplifications of the regions 11q13 (harboringCCND1,FADD andCTTN) and 11q22 (harboringBIRC2 andYAP1), in HPV-negative tumors, described to play an important role in pathogenesis and tumor development7. This evidence concerns the gene CASP8 and neoplasm.