“A predisposing factor inhip dysplasia etiology is ligamentous laxity, presented in more than half of thepatients with 3M syndrome described in the literature...3M syndrome is an autosomal recessive disorder. In2005, using an homozygosity mapping strategy, we have mapped the disease locus gene on chromosome6p21.1 and identified mutations in Cullin 7 (CUL7, KIAA0076) gene...WhileCUL7 appears to be the majorgene responsible for 3M syndrome accounting for 70% of our cases,...” Here, CUL7 is linked to 3M syndrome.